Promoting Excellence : Treatment Protocol for the Symptom of Restless Legs in ESRD

Renal Palliative Care Initiative: Treatment Protocol for the Symptom of Restless Legs in ESRD

This treatment protocol was created to address and manage occurrence of restless legs in patients with end stage renal disease.

Clinical Care Tools - Symptom Management

Renal Palliative Care Initiative
Baystate Medical Center
759 Chestnut Street S2669
Springfield, MA 01199

Michael Germain, M.D.
[email protected]

How the grantee used this instrument:
This protocol was made available at the clinics and renal unit nursing stations.

esrd, end stage renal disease, restless legs, dialysis, kidney disease, symptom assessment

To use this tool:
You may print and copy this tool for your own use from this site. Please credit source.


  1. Callaghan, N. "Restless Legs Syndrome in Uremic Neuropathy". Neurology 1966; 16: 359.
  2. Walker, S., Fine, A., & Kryger, M.H. "Sleep Complaints are Common in a Dialysis Unit". American Journal of Kidney Disease. 1995; 26:751.
  3. Harris, DC, Chapman, JR, Stewart, KH, et al. "Low Dose Erythropoietin in Maintenance Hemodialysis: Improvement in Quality of Life and Reduction in True Cost of Hemodialysis". Australia and New Zealand Journal of Medicine. 1991; 21:693.
  4. Roger, SD, Harris, DCH, & Stewart, JH. "Possible Relation Between Restless Legs and Anaemia in Renal Dialysis Patients". Lancet; 337: 1551.
  5. O'Keefe, St, Gavin, K, Lavan, JN. "Iron Status and Restless Leg Syndrome in the Elderly". Age Ageing, 1994;23:200.
  6. Collado-Seidel, V, Kohnen, R, Samtleben, W, et al. "Clinical and Biochemical Findings in Uremic Patients With and Without Restless Legs Syndrome". American Journal of Kidney Disease,1998; 31:132.
  7. Winkelman, JW, Cherow, GM, & Lazarus, JM. "Restless Legs Syndrome in End-Stage Renal Disease". American Journal of Kidney Disease, 1996; 28: 372.
  8. Hening, WA, "Therapeutic Approaches to Restless Legs Syndrome and Periodic Limb Movement Disorder". Hospital Medicine, 1997; 33: 135.
  9. Schenck, CH, Mahowald, MW, "Long-term, Nightly Benzodiazepine Treatment of Injurious Parasomnias and Other Disorders of Disrupted Nocturnal Sleep in 170 Adults. American Journal of Medicine, 1996; 100:333
  10. Allen, RP, & Earley, CJ, "Augmentation of the Restless Legs Syndrome with Carbidopa/Levodopa". Journal Sleep 1996; 19: 205.
  11. Von Scheele, C, Kempe, V, "Long-Term Effect of Dopaminergic Drugs in Restless Legs: A 2-year Follow-up". Arch Neurol 1990; 47:1223.
  12. Silber, MH, Shepart, JW Jr, Wisbey, JA, "Pergolide in the Management of Restless Legs Syndrome: An Extended Study. Journal Sleep, 1997; 20:878.
  13. Thorp, ML, Morris, CD, Bagby, SP, "A Crossover Study of Gabapentim in Treatment of Restless Legs Syndrome Among Hemodialysis Patients. American Journal of Kidney Disease, 2001;38:104.
  14. Wagner, ML, Walters, AS, Coleman,, "Randomized, Double-Blind, Placebo-Controlled Study of Clonidine in Restless Legs Syndrome". Advance for Managers of Respiratory Care, 1996; 19:52.
  15. Walters, AS, Wagner, ML, Hening, WA, et al., "Successful Treatment of the Idiopathic Restless Legs Syndrome in a Randomized Double-Blind Trial of Oxycodone Versus Placebo". Journal Sleep, 1993; 16:327.

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Posted April 2004

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# BMC12, type:symptom_management

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